Evaluation of Antihyperglycemic Effect of Epilobium parviflorum in High Fat Diet Fructose Streptozotocin Induced Type 2 Diabetic Albino Wistar Rats
By: RANAJIT, S. K
.
Contributor(s): Killari, K. N.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(3), May-June.Description: 547-555p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The proposed work deals with pharmacological evaluation of aqueous leaf extract ofEpilobium parviflorum
for antihyperglycemic and antihyperlipidemic activity in high fat diet fructose streptozotocin induced type
2 Diabetes mellitus in albino wistar rats. The experimental protocol was designed on a total of 30 rats,
equally divided into 5 groups (6 rats in each group). The high fat diet fructose was administered to all
the groups except the normal control group throughout a 6 w study period. A low dose of streptozotocin
(35 mg/kg body weight) is freshly prepared and administered intraperitoneally once after the initial 2 w
of high fat diet fructose administration. The animals were observed for 1 w to induce diabetes. The two
doses of aqueous leaf extract of Epilobium parviflorum (200 & 400 mg/kg) and pioglitazone (10 mg/kg)
were administered orally once daily throughout the rest 3 w. Various serum parameters including lipid
profile, liver profile, renal profile and inflammatory biomarkers were estimated on 0th and 6 th w of the
study. All the individual test results are falling within the normal distribution of the test groups (treatment
with leaf extract) when compared with disease control group with least variance (p<0.01). However, when
compared to the standard group (pioglitazone treated), the results show too much variance. Increase in
insulin release and decreased fasting blood sugar results are purely dose dependant. The histopathological
studies of hepatocyte, nephron, adipocytes and islet of pancreatic beta cells were also exhibited excellent
antihyperglycemic and antihyperlipidemic activity while the test group maintained normal cell
architectures. With the assumption on the traditional curative assurance and scientific evidences, it may be
concluded that Epilobium parviflorum contributes to the antihyperglycemic as well as antihyperlipidemic
activity by maintaining the normal structure and function of hepatocytes, renal, pancreas and adipose
function.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2021-2022564 |
The proposed work deals with pharmacological evaluation of aqueous leaf extract ofEpilobium parviflorum
for antihyperglycemic and antihyperlipidemic activity in high fat diet fructose streptozotocin induced type
2 Diabetes mellitus in albino wistar rats. The experimental protocol was designed on a total of 30 rats,
equally divided into 5 groups (6 rats in each group). The high fat diet fructose was administered to all
the groups except the normal control group throughout a 6 w study period. A low dose of streptozotocin
(35 mg/kg body weight) is freshly prepared and administered intraperitoneally once after the initial 2 w
of high fat diet fructose administration. The animals were observed for 1 w to induce diabetes. The two
doses of aqueous leaf extract of Epilobium parviflorum (200 & 400 mg/kg) and pioglitazone (10 mg/kg)
were administered orally once daily throughout the rest 3 w. Various serum parameters including lipid
profile, liver profile, renal profile and inflammatory biomarkers were estimated on 0th and 6 th w of the
study. All the individual test results are falling within the normal distribution of the test groups (treatment
with leaf extract) when compared with disease control group with least variance (p<0.01). However, when
compared to the standard group (pioglitazone treated), the results show too much variance. Increase in
insulin release and decreased fasting blood sugar results are purely dose dependant. The histopathological
studies of hepatocyte, nephron, adipocytes and islet of pancreatic beta cells were also exhibited excellent
antihyperglycemic and antihyperlipidemic activity while the test group maintained normal cell
architectures. With the assumption on the traditional curative assurance and scientific evidences, it may be
concluded that Epilobium parviflorum contributes to the antihyperglycemic as well as antihyperlipidemic
activity by maintaining the normal structure and function of hepatocytes, renal, pancreas and adipose
function.
Click on an image to view it in the image viewer
There are no comments for this item.